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OPTIMASI FORMULA SAMPO EKSTRAK ETANOL DAUN DELIMA (Punica granatum L.) DENGAN METODE SIMPLEX LATTICE DESIGN

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ABSTRAK
Sampo antiketombe yang beredar di pasaran masih menggunakan zat aktif
sintetik salah satunya zink piriton yang memiliki efek samping menyebabkan
kerontokan rambut dan rasa sakit pada kulit kepala. Daun delima (Punica granatum
L.) dengan kandungan metabolit sekunder seperti alkaloid, flavonoid, saponin,
tanin, dan terpenoid memiliki aktivitas antijamur yang kuat terhadap jamur
penyebab ketombe. Daun delima dapat dimanfaatkan sebagai agen antiketombe
dalam bentuk sediaan sampo untuk memudahkan dalam pengaplikasiannya dan
meningkatkan kenyamanan pengguna. Penelitian ini bertujuan untuk menentukan
formula optimum dan sifat fisik sediaan sampo daun delima dengan variasi
surfaktan sodium lauril sulfat (SLS) dan cocamide DEA. Ekstrak etanol daun
delima diperoleh dengan metode sokletasi dan identifikasi metabolit sekunder yang
terkandung dengan uji tabung. Delapan rancangan formula sampo ditentukan
menggunakan metode SLD (Simplex Lattice Design) dengan software Design
Expert 13. Sediaan sampo dievaluasi sifat fisik meliputi uji tinggi busa, pH, dan
viskositas sebagai respon untuk memperoleh formula optimum. Sediaan optimum
sampo diuji sifat fisik meliputi uji organoleptis, homogenitas, stabilitas busa, tinggi
busa, pH, dan viskositas. Hasil uji sifat fisik sediaan sampo optimum diverifikasi
menggunakan aplikasi SPSS dengan metode one-sample t-test. Ekstrak etanol daun
delima positif mengandung alkaloid, flavonoid, tanin dan saponin. Hasil optimasi
diperoleh formula optimum sampo yaitu kombinasi SLS 5,5% dan cocamide DEA
15,5%. Sampo formula optimum memiliki warna hitam, bau seperti menthol,
bentuk seperti gel, bahan tercampur secara homogen, stabilitas busa sebesar
81,83%, nilai tinggi busa 9,30 ? 0,26 cm, pH 5,91 ? 0,45, dan viskositas 1646,66 ?
220,23 cP. Sediaan sampo ekstrak etanol daun delima memenuhi syarat sifat fisik
sampo.
Kata Kunci : daun delima, ketombe, optimasi, sampo, simplex lattice design.viii
ABSTRACT
Anti-dandruff shampoos on the market still use synthetic active substances,
one of which is zinc pyriton, which has the side effect of causing hair loss and scalp
pain. Pomegranate leaves (Punica granatum L.) containing secondary metabolites
such as alkaloids, flavonoids, saponins, tannins, and terpenoids have strong
antifungal activity against dandruff-causing fungi. Pomegranate leaves can be used
as an anti-dandruff agent in shampoo to facilitate its application and increase user
comfort. This study aims to determine the optimum formula and physical properties
of pomegranate leaf shampoo with variations of sodium lauryl sulfate and cocamide
DEA surfactants. The ethanol extract of pomegranate leaves was obtained by
soxhletation method and identification of the secondary metabolites contained by a
tube test. Eight shampoo formula designs were determined using the SLD (Simplex
Lattice Design) method with Design Expert 13 software. The shampoo was
evaluated for physical properties including height of foam, pH, and viscosity tests
as a response to obtain the optimum formula. The optimum shampoo was tested for
physical properties including organoleptic tests, homogeneity, foam stability,
height of foam, pH, and viscosity. The test results for the physical properties of the
optimum shampoo were verified using the SPSS application with the one-sample ttest method. Pomegranate leaves ethanol extract positively contains alkaloids,
flavonoids, tannins, and saponins. Optimization results obtained the optimum
shampoo formula that is a combination of 5.5% SLS and 15.5% cocamide DEA.
The optimum formula shampoo has a black color, smells like menthol, a gel-like
form, the ingredients are mixed homogeneously, foam stability is 81,83%, foam
height value is 9.30 ? 0.26 cm, pH is 5.91 ? 0.45, and viscosity is 1646. 66 ? 220.23
cP. Pomegranate leaf ethanol extract shampoo complied with the physical
characteristics of the shampoo.
Keywords: dandruff, optimization, pomegranate leaves, shampoo, simplex lattice
design.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

212

Penerbit

Mataram : Farmasi FK Unram., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

DTS 610 Syi o F.2023

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

-

Subjek

SKRIPSI

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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