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PERBANDINGAN HASIL POINT OF CARE TESTING (POCT) ASAM URAT DENGAN CHEMISTRY ANALYZER

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ABSTRAK
PERBANDINGAN HASIL POINT OF CARE TESTING (POCT) ASAM URAT DENGAN CHEMISTRY ANALYZER
Dewi Rabiatul Akhzami, Mohammad Rizki, Rika Hastuti Setyorini
Latar belakang: Hiperurisemia merupakan peningkatan kadar asam urat dalam darah. Pada dekade terakhir prevalensi penderita hiperurisemia cenderung meningkat di seluruh dunia. Oleh karena itu, dibutuhkan pemeriksaan laboratorium untuk mengetahui kadar asam urat dalam darah. Alat yang telah digunakan sebagai alat standar dalam pemeriksaan laboratorium adalah chemistry analyzer. Seiring dengan perkembangan teknologi dan pengetahuan, terdapat alat lain yang dapat digunakan dalam pemeriksaan laboratorium yaitu point of care testing (POCT).
Tujuan: Mengetahui perbedaan hasil antara point of care testing (POCT) asam urat dengan chemistry analyzer.
Metode: Penelitian ini menggunakan desain studi perbandingan dengan metode potong lintang (cross-sectional). Pengambilan sampel penelitian dilakukan di Kelurahan Karang Pule dan Kelurahan Tanjung Karang dengan metode cluster sampling, kemudian dari kedua kelurahan tersebut, sampel penelitian diambil dengan tehnik consecutive sampling dan memenuhi kriteria inklusi (n=42). Selanjutnya dilakukan pengambilan sampel darah dari vena antecubital pada penduduk yang masuk sebagai sampel penelitian, kemudian dilakukan pemeriksaan dengan point of care testing (POCT) dan chemistry analyzer. Uji statistika yang digunakan yaitu uji Wilcoxon untuk mengetahui perbedaan hasil pemeriksaan asam urat antara alat POCT dan chemistry analyzer.
Hasil: Kadar asam urat serum yang diperiksa dengan point of care testing (POCT) dengan strip/stik berkisar antara 3,1-11,1 mg/dl dengan nilai tengah 5,65 mg/dl dan simpangan kuartil (interquartile range [IQR]) 7,4 mg/dl sedangkan kadar asam urat serum responden yang diperiksa dengan menggunakan chemistry analyzer dengan Cobas® berkisar antara 3,1-12,3 mg/dl dengan nilai tengah 5,45 mg/dl dan simpangan kuartil (interquartile range [IQR]) 7,1 mg/dl. Tidak terdapat perbedaan yang signifikan antara pemeriksaan asam urat dengan POCT dan chemistry analyzer (p=0,7460; uji Wilcoxon).
Kesimpulan: Tidak terdapat perbedaan hasil antara point of care testing (POCT) asam urat dengan chemistry analyzer.
Kata kunci: Asam urat, hiperurisemia, point of care testing (POCT), chemistry analyzer.





ABSTRACT
THE COMPARISON RESULTS OF POINT OF CARE TESTING (POCT) URIC ACID WITH CHEMISTRY ANALYZER
Dewi Rabiatul Akhzami, Mohammad Rizki, Rika Hastuti Setyorini
Background: Hyperuricemia means there are increased levels of uric acid in the blood. In the last decade, the prevalence of hyperuricemia tend to increase around the world. Therefore, laboratory tests to determine the levels of uric acid in the blood are required. The equipment that has been used as the standard measurement in the laboratory examination is chemistry analyzer. Along with the development of technology and knowledge, point of care testing (POCT) also created as new equipment to measure uric acid blood level in laboratory.
Objective: To know the difference of results between uric acid examination by point of care testing (POCT) and chemistry analyzer.
Method: This study uses a comparative study design with cross-sectional method. The sample was conducted in the village of Karang Pule and Tanjung Karang with cluster sampling method, then from the two villages, the study sample was taken with consecutive sampling techniques and met the inclusion criteria (n=42). The blood samples that were taken from the antecubital vein were examined by point of care testing (POCT) and chemistry analyzer. Wilcoxon test was used to determine the differences between the results of POCT and chemistry analyzer as the uric acid examination instrument.
Results: Uric acid serum levels were examined by point of care testing (POCT) with strips/sticks ranged from 3.1 to 11.1 mg/dl with a median value of 5.65 mg/dl and interquartile range (IQR) 7,4 mg/dl, whereas uric acid serum levels of the respondent were examined by using chemistry analyzer with Cobas® ranged from 3.1 to 12.3 mg/dl with a median value of 5.45 mg/dl and interquartile range (IQR) 7,1 mg/dl. There were no significant differences between uric acid examination by POCT and chemistry analyzer (p=0.7460; Wilcoxon test).
Conclusion: There is no significant difference of results between uric acid examination by point of care testing (POCT) and chemistry analyzer.

Keywords: Uric acid, hyperuricemia, point of care testing (POCT), chemistry analyzer.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

537

Penerbit

Mataram : Fakultas Kedokteran Universitas Mataram., 2016

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

616.399

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KTI
POCT
hiperurisemia
Asam urat
Uric acid
hyperuricemia
KTI PSPD

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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