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HUBUNGAN KADAR FOSFAT SERUM DAN CAROTID INTIMA MEDIA THICKNESS PADA PASIEN GAGAL GINJAL KRONIS YANG MENJALANI HEMODIALISIS DI RSUD PROVINSI NTB
ABSTRAK
HUBUNGAN KADAR FOSFAT SERUM DAN CAROTID INTIMA MEDIA
THICKNESS PADA PASIEN GAGAL GINJAL KRONIS YANG
MENJALANI HEMODIALISIS DI RSUD PROVINSI NTB
Ida Bagus Putra Bayu Aryasta, Yusra Pintaningrum, Romi Ermawan
Latar belakang: Gagal ginjal kronis (GGK) merupakan masalah kesehatan global
yang meningkatkan risiko penyakit kardiovaskular, salah satunya melalui
aterosklerosis yang dapat dinilai secara non-invasif dengan carotid intima-media
thickness (CIMT). Kondisi hiperfosfatemia pada pasien GGK diketahui berperan
dalam kalsifikasi vaskular, namun hubungannya dengan peningkatan CIMT pada
pasien yang menjalani hemodialisis masih belum jelas. Penelitian ini bertujuan
untuk menganalisis hubungan kadar fosfat serum dengan CIMT pada pasien GGK
di RSUD Provinsi NTB.
Metode: Penelitian ini merupakan penelitian observasional analitik dengan
rancangan cross-sectional yang dilakukan di RSUD Provinsi NTB. Pasien GGK
yang menjalani hemodialisis dan telah memenuhi kriteria penelitian diikutsertakan.
Data yang dikumpulkan meliputi kadar fosfat serum, pengukuran CIMT dengan
ultrasonografi B-mode, serta karakteristik demografis dan klinis. Pengolahan dan
analisis statistik menggunakan uji korelasi Spearman dan Mann-Whitney U.
Hasil: Sebanyak 62 pasien diikutsertakan (40 laki-laki, 22 perempuan; usia ratarata 50,8 ? 12,15 tahun). Median CIMT pasien adalah 0,70 mm (0,63 ? 0,77) dan
kadar fosfat serum 4,50 mg/dL (3,97 ? 5,60). CIMT berkorelasi lemah dan
signifikan dengan kadar fosfat serum pada seluruh pasien (r = 0,292; P=0,021).
Kesimpulan: Terdapat korelasi positif lemah antara kadar fosfat serum dan CIMT
pada pasien GGK yang menjalani hemodialisis.
Kata kunci: gagal ginjal kronis, hemodialisis, fosfat serum, ketebalan intimamedia arteri karotis, kalsifikasi vaskularix
ABSTRACT
CORRELATION OF SERUM PHOSPHATE LEVELS AND CAROTID
INTIMA MEDIA THICKNESS IN CHRONIC KIDNEY DISEASE
PATIENTS UNDERGOING HEMODIALYSIS AT THE WEST NUSA
TENGGARA PROVINCIAL HOSPITAL
Ida Bagus Putra Bayu Aryasta, Yusra Pintaningrum, Romi Ermawan
Background: Chronic kidney disease (CKD) is a global health problem that
increases the risk of cardiovascular disease, partly through atherosclerosis, which
can be assessed non-invasively using carotid intima-media thickness (CIMT).
Hyperphosphatemia in CKD patients is known to contribute to vascular
calcification; however, its association with increased CIMT in patients undergoing
hemodialysis remains unclear. This study aimed to analyze the relationship between
serum phosphate levels and CIMT in CKD patients at the West Nusa Tenggara
Provincial Hospital.
Method: This was an analytical observational study with a cross-sectional design
conducted at West Nusa Tenggara Provincial General Hospital. CKD patients
undergoing hemodialysis who met the inclusion criteria were enrolled. Data
collected included serum phosphate levels, CIMT measurements using B-mode
ultrasonography, and demographic and clinical characteristics. Statistical analysis
was performed using Spearman?s correlation test and the Mann-Whitney U test.
Result: A total of 62 patients were included (40 males, 22 females; mean age 50.8
? 12.15 years). The median CIMT was 0.70 mm (0.63?0.77) and serum phosphate
level was 4.50 mg/dL (3.97?5.60). When all study subjects were analyzed as a
single group, CIMT showed a weak but significant correlation with serum
phosphate levels (r = 0.292; P = 0.021).
Conclusion: There is a weak positive correlation between serum phosphate levels
and CIMT in CKD patients undergoing hemodialysis.
Key word: chronic kidney disease, hemodialysis, serum phosphate, carotid intimamedia thickness, vascular calcification
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