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FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI KRIM ANTIJERAWAT EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam.) TERHADAP Staphylococcus epidermidis

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ABSTRAK
Prevalensi jerawat dalam masa remaja dan resistensi antibiotik yang tinggi
mendorong eksplorasi alternatif antibiotik berbasis herbal. Daun kelor (Moringa
oleifera Lam.) merupakan tanaman yang memiliki aktivitas antibakteri karena
mengandung senyawa flavonoid, alkaloid, tanin, dan saponin. Penelitian ini
bertujuan memformulasi krim antijerawat ekstrak etanol daun kelor dan menguji
aktivitasnya terhadap Staphylococcus epidermidis. Metode penelitian yang
dilakukan yaitu uji aktivitas antibakteri ekstrak, formulasi krim antijerawat tipe
M/A konsentrasi (5%, 10%, dan 15%), evaluasi serta uji aktivitas antibakteri krim
antijerawat. Pengujian aktivitas antibakteri dilakukan dengan metode well diffusion.
Efektivitas ekstrak dan krim antijerawat diamati dengan melihat diameter zona
hambat bakteri. Analisis data menggunakan uji One Way ANOVA dan Independent
T-Test dengan program spss. Diperoleh diameter zona hambat ekstrak etanol daun
kelor dengan konsentrasi 5%, 10%, serta 15% secara berurut yaitu : 23.01 mm,
23.34 mm, dan 23.68 mm. Hasil ini menunjukkan tidak ada perbedaan yang
signifikan antar konsentrasi ekstrak. Diameter zona hambat krim antijerawat
ekstrak etanol daun kelor dengan konsentrasi 5%, 10%, serta 15% secara berurut
yaitu : 11.31 mm, 11.85 mm, dan 12.33 mm. Terdapat perbedaan diameter zona
hambat yang signifikan dari konsentrasi ekstrak 5% dan 15% dalam krim
antijerawat dengan nilai p ˂ 0.05. Dapat disimpulkan kekuatan krim antijerawat
dalam menghambat Staphylococcus epidermidis belum sebanding dengan
klindamisin yang merupakan lini pertama dalam pengobatan jerawat.
Kata kunci: Jerawat, Krim Antijerawat, Daun Kelor.vii
ABSTRACT
The prevalence of acne in adolescence and high antibiotic resistance
encourages the exploration of herbal-based antibiotic alternatives. Moringa leaves
(Moringa oleifera Lam.) are plants that have antibacterial activity because they
contain compounds of flavonoids, alkaloids, tannins, and saponins. The aim of
researsch to formulate an anti-acne cream ethanol extract of Moringa leaves and
test its activity against Staphylococcus epidermidis. The research methods used
were antibacterial activity extract test, M/A type anti-acne cream formulation
concentration (5%, 10%, and 15%), evaluation and antibacterial activity test for
anti-acne cream. Antibacterial activity testing was carried out by the well diffusion
method. The effectiveness of antibacterial extracts and creams was observed by
looking at the diameter of the bacterial inhibitory zone. Data analysis using the One
Way ANOVA test and Independent T-Test with the SPSS program. Obtained
diameter inhibition zone of Moringa leaf ethanol extract with a concentration of
5%, 10%, and 15% in sequence, namely: 23.01 mm, 23.34 mm and 23.68 mm.
These results showed no significant difference between extract concentrations. The
diameter of the anti-acne cream inhibition zone ethanolic extract of Moringa leaves
with a concentration of 5%, 10%, and 15% in sequence, namely: 11.31 mm, 11.85
mm, and 12.33 mm. There was significant difference in inhibition zone diameters
from extract concentrations of 5% and 15% in anti-acne creams with a p value of
< 0,05. It could be concluded that the strength of anti-acne cream in inhibiting
Staphylococcus epidermidis was not comparable with clindamycin which is the first
line in acne treatment.
Keywords: Acne, Anti-acne Cream, Moringa oleifera Lam. Leaf.

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Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

047

Penerbit

Mataram : Universitas Mataram., 2019

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

047

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

-

Subjek

SKRIPSI

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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